Does you radio look like
A)

or B)
If A there is a little more work and wiring involved. If B then a little simpler.
Either you will have to run the following wiring for both:
- RCA from radio to amp
- Remote turn on from radio to amp
- speaker wire from amp to speakers
Difference is if you have radio a you need to buy a low pass converter for about $10 to $20 (depending on prices in your area) and splice into the speaker wires coming off the radio to connect the low pass converter. This will allow you to run RCAs from radio to AMP. If you have Radio B it already has the preamp outputs on the back of the radio. Also with Radio B you have controls through the radio to change the setup for the signal going to the amp from the radio. With Radio A you do not.
Either way it is not hard just a little less work for one then the other. and a little more control ability.